Prof. Guoying Yu, Henan Normal University, China
Professor Guoying Yu is a distinguished biomedical scientist and professor at the College of Life Sciences, Henan Normal University, China. With a Ph.D. in Ecology from the Chinese Academy of Sciences and postdoctoral experience at Yale and the University of Pittsburgh, Dr. Yu has made significant contributions to lung biology, focusing on acute lung injury, pulmonary fibrosis, and thyroid hormone-based therapies. His innovative research has been published in top-tier journals like Nature Communications and Advanced Science, and he has secured major national and provincial research grants. A leader in translational medicine, Dr. Yu is widely respected for his impactful work, international collaborations, and dedication to advancing global health through scientific innovation.
Profile
Scopus
🏫 Early Academic Pursuits
Professor Guoying Yu’s journey into science began with a deep-rooted passion for biology and ecology. Born in China, he pursued his undergraduate studies at Henan Normal University, graduating in 1985 with a strong academic foundation in life sciences. Determined to explore ecological systems at a deeper level, he obtained his Master’s degree from Yunnan University in 1989. His unwavering commitment to academic excellence propelled him toward doctoral studies, and he earned his Ph.D. in Ecology in 1995 from the Chinese Academy of Sciences, China’s leading research institution.
Dr. Yu’s Ph.D. work laid a critical foundation in interdisciplinary environmental biology, a focus that later expanded into biomedical research. His academic brilliance and research discipline were evident from these formative years, building a strong base for his future endeavors.
👨🔬 Professional Endeavors
After receiving his Ph.D., Dr. Yu broadened his horizons through prestigious postdoctoral fellowships at the University of Pittsburgh (USA) and the Chinese Academy of Sciences. His research during this period focused on biomedical applications of molecular ecology, marking his transition into translational and clinical research.
Over the years, he has held esteemed research and academic positions at globally recognized institutions including Yale University, University of Pittsburgh, and Chinese academic universities. Currently, Dr. Yu is a Professor at the College of Life Sciences at Henan Normal University, where he leads critical research in lung injury, pulmonary fibrosis, and drug development.
His career is characterized by a fusion of academic rigor and innovation, with a particular focus on diseases that have significant public health impacts.
🔬 Contributions and Research Focus
Professor Yu’s research spans molecular biology, immunology, pulmonary disease, and translational medicine. A notable area of focus has been his exploration of thyroid hormone analogs, especially GC-1, for the treatment of acute lung injury and pulmonary fibrosis. His findings have significantly contributed to the non-steroidal therapeutic approach to lung repair.
Some of his groundbreaking work includes:
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The TRβ/KLF2/CEBPA axis, which enhances alveolar repair by guiding alveolar type 2 to type 1 cell differentiation.
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The inhibition of macrophage inflammasomes to control cytokine storms and lung injury.
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The identification of MMP19 from endothelial cells as a critical contributor to pulmonary fibrosis.
His work integrates molecular mechanisms with clinical application and has been published in top-tier journals such as Nature Communications, Advanced Science, Theranostics, and Cell Communication and Signaling.
🏅 Accolades and Recognition
Dr. Yu’s research excellence has earned him national and provincial funding awards from:
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National Key Research and Development Program (2020–2023) – ¥2.85 million
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Zhongyuan Foreign Expert Program (2020–2021) – ¥220,000
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Henan Major Scientific and Technological Projects (2024–2026) – ¥2 million
He is recognized as a leading talent in Henan Province, and has been entrusted with managing high-impact biomedical research projects. His leadership roles in academic and governmental collaborations underscore his credibility as a national research leader.
🌍 Impact and Influence
Dr. Yu’s influence transcends borders. His international collaborations, particularly with institutions in the United States such as Yale and Pittsburgh, have facilitated the global exchange of knowledge. His work on post-COVID-19 lung pathology, innovative drug discovery, and inflammation control strategies have directly impacted public health strategies and pharmaceutical development in China.
With over 1,300 citations and increasing global interest in his work, Dr. Yu is regarded as an authority in pulmonary disease mechanisms, especially within the translational research community.
🌱 Legacy and Future Contributions
Professor Guoying Yu’s legacy lies in his ability to bridge scientific innovation with practical application. As a mentor, he continues to shape the next generation of scientists at Henan Normal University. As a scientific leader, his vision for the future includes:
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Developing affordable therapies for lung diseases in low- and middle-income countries.
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Enhancing China’s biomedical innovation pipeline through international cooperation.
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Advancing precision medicine approaches tailored to complex respiratory conditions.
His ongoing work positions him not only as a trailblazer in translational lung biology but also as a guiding force for future biomedical innovation in Asia and beyond.
Publication Top Notes
Author: Z., Li, Zhongzheng, M., Zhang, Mengke, Y., Zhang, Yujie, … G., Yu, Guoying, L., Wang, Lan
Journal: Epigenetics and Chromatin
Year: 2025
Author: H., Lian, Hui, Y., Zhang, Yujie, Z., Zhu, Zhao, … L., Wang, Lan, G., Yu, Guoying
Journal: Life Science Alliance
Year: 2025
Author: X., Pan, Xin, L., Wang, Lan, J., Yang, Juntang, … I.O., Rosas, Ivan O., G., Yu, Guoying
Journal: Nature Communications
Year: 2024