Gustavo Maegawa | Biochemistry | Innovative Research Award

Innovative Research Award

Gustavo Maegawa — Columbia University Irving Medical Center, United States

Gustavo Maegawa
Affiliation Columbia University Irving Medical Center
Country United States
Scopus ID 14522943200
Documents 54
Citations 2,549
h-index 25
Subject Area Biochemistry
Event International Research Awards
ORCID 0000-0001-6933-4138

Gustavo Maegawa is a physician-scientist and academic researcher affiliated with Columbia University Irving Medical Center. His documented academic work includes clinical genetics, genomics, lysosomal storage disorders, and biochemical research, with publications addressing inherited metabolic diseases and related molecular mechanisms. Bibliographic records supplied for this recognition profile report 54 documents, 2,549 citations, and an h-index of 25.[1]

Abstract

Gustavo Maegawa is a physician-scientist affiliated with Columbia University Irving Medical Center whose research spans clinical genetics, genomics, biochemical investigation, and lysosomal storage disorders. His academic record includes research addressing inherited metabolic diseases and molecular mechanisms relevant to rare disorders. Publicly indexed publications identify his participation in multidisciplinary studies involving disease mechanisms, screening, therapeutic development, and molecular characterization.[1][2] Bibliographic information supplied for this profile records 54 documents, 2,549 citations, and an h-index of 25. His research activity therefore provides a basis for recognition under an Innovative Research Award framework, particularly through sustained scholarly contribution and interdisciplinary biomedical investigation. Recent publications further demonstrate continued involvement in research on lysosomal and inherited metabolic disorders.[1]

Keywords

Gustavo Maegawa; Innovative Research Award; Columbia University Irving Medical Center; biochemistry; clinical genetics; genomics; lysosomal storage disorders; inherited metabolic diseases; rare diseases; biomedical research; translational research; molecular medicine.[1]

Introduction

Gustavo Maegawa is identified by Columbia University as an Associate Professor of Pediatrics with academic expertise in clinical genetics and genomics. His research has focused particularly on lysosomal storage disorders, a group of inherited metabolic conditions involving defects in cellular degradation pathways.[1]

Research Profile

The research profile associated with Gustavo Maegawa encompasses clinical genetics, genomics, biochemical research, and lysosomal storage disorders. Columbia University describes his research focus as including lysosomal storage disorders and his professional expertise as clinical genetics and genomics.[1]

Research Contributions

His publication record also includes research related to newborn screening for lysosomal storage disorders. A 2024 study examining screening for six lysosomal storage disorders in China included Maegawa as a co-author and identified Columbia University affiliations.[5]

Publications

Selected publications involving Gustavo Maegawa demonstrate a research emphasis on rare diseases, inherited metabolic disorders, molecular mechanisms, and translational biomedical investigation. The following examples are drawn from indexed bibliographic records and are presented as representative publications rather than as a complete bibliography.[1]

Research Impact

Beyond citation indicators, the subject areas represented in the publication record are relevant to clinical genetics and rare-disease research. Studies involving lysosomal storage disorders, genetic screening, molecular mechanisms, and potential therapeutic strategies demonstrate connections between laboratory investigation and clinically relevant questions.[3][5]

Award Suitability

The Innovative Research Award is aligned with a research profile demonstrating sustained scholarly activity and contributions to scientific investigation. Gustavo Maegawa’s documented work in clinical genetics, genomics, biochemical research, and lysosomal storage disorders provides a relevant academic basis for consideration under this recognition category.[1]

Conclusion

Gustavo Maegawa’s research profile reflects sustained involvement in clinical genetics, genomics, biochemistry, and lysosomal storage disorder research. His publications address clinically and biologically significant questions involving inherited metabolic diseases, screening, molecular mechanisms, and therapeutic investigation.[3][4]

References

  1. Begum, S., Hsueh, S.-C., Cheria, E. M. Y., et al. Sphingolipid-neutralizing molecular therapy reduces psychosine cytotoxicity in Krabbe disease. iScience, 29(3), 114808, 2026. DOI: https://doi.org/10.1016/j.isci.2026.114808
  2. Yi, M., Wang, Y., Gao, X., et al. Investigation of GALNS variants and genotype-phenotype correlations in a large cohort of patients with mucopolysaccharidosis type IVA. Journal of Inherited Metabolic Disease, 45(3), 593–604, 2022.
    https://doi.org/10.1002/jimd.12491
  3. Maegawa, G. H. B., Tropak, M. B., Buttner, J. D., Rigat, B. A., Fuller, M., Pandit, D., Tang, L., Kornhaber, G. J., Hamuro, Y., Clarke, J. T. R., & Mahuran, D. J. (2009). Identification and characterization of ambroxol as an enzyme enhancement agent for Gaucher disease. Journal of Biological Chemistry, 284(35), 23502–23516.
    https://doi.org/10.1074/jbc.M109.012393

  4. Santelices, J., Ou, M., Maegawa, G. H. B., et al. USP8 inhibition regulates autophagy flux and controls Salmonella infection. Frontiers in Cellular and Infection Microbiology, 13, 1070271, 2023.  https://doi.org/10.3389/fcimb.2023.1070271
  5. Mallack, E. J., Turk, B. R., Yan, H., Price, C., Demetres, M., Moser, A. B., Becker, C., Hollandsworth, K., Adang, L., Vanderver, A., & Van Haren, K. (2021). MRI surveillance of boys with X-linked adrenoleukodystrophy identified by newborn screening: Meta-analysis and consensus guidelines. Journal of Inherited Metabolic Disease.
    https://doi.org/10.1002/jimd.12356 

Peter Hristov | Biochemistry | Editorial Board Member

Prof Dr. Peter Hristov | Biochemistry | Editorial Board Member

Institute of Biodiversity and Ecosystem Research – Bulgarian Academy of Sciences (IBER-BAS) | Bulgaria

Prof. Dr. Peter Ivanov Hristov is a distinguished Bulgarian molecular biologist and biochemist whose work has significantly advanced the understanding of animal genetic diversity, molecular phylogeny, and population structure in domestic and wild species. Currently serving as a Professor at the Institute of Biodiversity and Ecosystem Research (IBER) at the Bulgarian Academy of Sciences, he has built a rigorous academic career grounded in molecular genetics, evolutionary biology, and biodiversity conservation. Prof. Hristov earned his Master’s degree from Trakia University in 1999, followed by a Ph.D. in 2005 from the Institute of Biology and Immunology of Reproduction at BAS. Over the past decade, he has progressed through academic ranks, serving as Chief Assistant (2010–2015), Associate Professor (2015–2021), and Professor (2021–present), reflecting his longstanding contributions to the field. His primary research areas include biochemistry, molecular biology, molecular phylogeny, population structure studies, and taxonomic research, complemented by strong expertise in bioinformatics and the statistical processing of molecular data. His involvement in international scientific collaborations includes participation in the EU’s Sixth Framework Programme—DeLiver Project (2007–2011)—demonstrating his engagement in large-scale, interdisciplinary research initiatives. Prof. Hristov’s scientific output is extensive and influential. He has authored 83 scientific publications, 59 of which appear in impact-factor or indexed journals, accumulating over 665 citations, with an h-index of 13 (Scopus). Remarkably, in the last five years alone, he has produced 40 publications, all in indexed journals, underscoring his active and consistent research productivity. His work spans genetic differentiation in livestock breeds, molecular detection of bee pathogens, mitochondrial DNA analyses, and phylogenetic exploration across various species. Key recent studies include genetic structure analysis of Bulgarian goat and horse breeds (Diversity, 2024), molecular pathogen detection in honey bees (Veterinary Sciences, 2023), and mitochondrial sequencing contributions revealing domestication centers in horse lineages (Journal of Equine Veterinary Science, 2022). His research also provides crucial insights into livestock conservation, biodiversity monitoring, and the application of molecular tools in animal breeding and health management. Prof. Hristov is widely recognized in the scientific community, publishing internationally under the name Peter Hristov and maintaining active research profiles on Scopus, ResearchGate, and ORCID. His work continues to bridge molecular science and biodiversity conservation, reinforcing his role as a leading figure in genetic research within Bulgaria and beyond.

Profile: Orcid

Featured Publications

Radoslavov, G., Kalaydzhiev, G., Yordanov, G., Palova, N., Salkova, D., & Hristov, P. (2025). Genetic diversity of native Bulgarian sheep breeds based on the mitochondrial D-loop sequence analysis. Small Ruminant Research, 108, 107527.

Yordanov, G., Yordanov, T., Mehandjyiski, I., Radoslavov, G., Salkova, D., & Hristov, P. (2025). Population structure and genetic diversity among Shagya Arabian horse genealogical lineages in Bulgaria based on microsatellite genotyping. Veterinary Sciences, 12(8), 776.

Stoeva, D., Gencheva, D., Radoslavov, G., Hristov, P., Yordanova, R., & Beev, G. (2025). Novel DNA barcoding and multiplex PCR strategy for the molecular identification and mycotoxin gene detection of Fusarium spp. in maize from Bulgaria. Methods and Protocols, 8(4), 78.

Salkova, D., Balkanska, R., Shumkova, R., Lazarova, S., Radoslavov, G., & Hristov, P. (2024). Molecular detection and phylogenetic relationships of honey bee-associated viruses in bee products. Veterinary Sciences, 11(8), 369.

Yordanov, G., Kalaydzhiev, G., Palova, N., Salkova, D., Lozanova, L., Dundarova, H., Odjakova, T., Todorov, P., Radoslavov, G., & Hristov, P. (2024). Genetic differentiation and population structure of two Bulgarian local goat breeds using microsatellite markers. Diversity, 16(7), 388.

Hristov, P., Radoslavov, G., Mehandjyiski, I., Salkova, D., & Yordanov, G. (2024). Genetic diversity and population structure among Arabian horse genealogical lineages in Bulgaria. Diversity, 16(5), 281.

Kalaydzhiev, G., Palova, N., Dundarova, H., Lozanova, L., Mehandjyiski, I., Radoslavov, G., & Hristov, P. (2023). Mitochondrial diversity and phylogenetic relationship of eight native Bulgarian sheep breeds. Animals, 13(23), 3655.