Bijo Mathew | Medicinal Chemistry | Best Researcher Award

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Prof Dr. Bijo Mathew | Medicinal Chemistry | Best Researcher Award

Professor at Amrita School of Pharmacy India.

Prof. Dr. Bijo Mathew is a distinguished academic in pharmaceutical sciences, currently serving as a Professor at Amrita School of Pharmacy, Amrita Vishwa Vidyapeetham, Kochi. With a robust background in molecular docking and drug design using AutoDock 4.2, Biovia, and Glide, he contributes significantly as Section Editor for Coronaviruses (BenthamScience) and Editorial Member for several prestigious journals. Dr. Mathew’s teaching career spans from Assistant Professor to his current role, imparting knowledge across various institutions in India. He is a sought-after speaker, delivering talks internationally and nationally on drug design and medicinal chemistry. Recognized as one of the Top 2% Scientists by Stanford, he has received multiple awards including the Amrita Publication Research Award and Best International Collaborator Award. Dr. Mathew holds patents for compositions addressing neurological disorders, underscoring his commitment to advancing pharmaceutical research and education.

Professional Profiles:

šŸŽ“ Education

Prof. Dr. Bijo Mathew boasts a distinguished academic journey in pharmaceutical sciences, culminating in a Ph.D. from Jawaharlal Nehru Technological University, Hyderabad, India, specializing in Pharmaceutical Science. Prior to his doctoral studies, he completed his Master’s in Pharmaceutical Chemistry and Bachelor’s in Pharmacy at The Tamilnadu Dr. M.G.R. Medical University, Chennai, and his pre-degree at Mahatma Gandhi University, Kottayam, India. His doctoral research under the guidance of Dr. A. Jerad Suresh focused on the synthesis, characterization, and pharmacological evaluation of heterocyclic derivatives, contributing significantly to the field. Prof. Mathew’s academic journey is marked by a commitment to advancing pharmaceutical knowledge, evident in his extensive expertise across various domains of pharmaceutical research, including molecular docking, dynamics, and pharmacophore mapping. His educational foundation and research acumen continue to drive innovative contributions in drug discovery and development, positioning him as a prominent figure in academia and pharmaceutical research.

Area of Interest and Expertise

Prof. Dr. Bijo Mathew’s research interests encompass a diverse array of fields within pharmaceutical chemistry and drug discovery. His expertise spans the chemistry and biological exploration of various classes of compounds such as chalcones and isatins. He is involved in the synthesis and pharmacological evaluation of heterocyclic nuclei including benzimidazole, thiadiazole, pyrimidine, furan, pyrazoline, and thiazole derivatives, focusing on their potential as CNS depressants, anticonvulsants, anticancer agents, antioxidants, and neuroprotective compounds. Dr. Mathew specializes in designing inhibitors for key enzymes like MAO, AChE, BACE1, and Hsp90, utilizing techniques such as monowave-assisted synthesis and structural elucidation through IR, NMR, and MASS spectroscopy. His research also extends to molecular docking, dynamics, pharmacophore mapping, and 3D-QSAR studies, as well as the isolation and computational analysis of natural secondary metabolites from medicinal plants.

Expertise in Software:

  • AutoDock 4.2, Biovia, Glide

Editorial Contributions:

  • Section Editor for Coronaviruses (BenthamScience)
  • Editorial Member for Brain Sciences (MDPI), Combinatorial Chemistry & High Throughput Screening (Bentham Science), Molecules (MDPI), Current Topics in Medicinal Chemistry (Bentham Science), Current Drug Targets (Bentham Science)

Teaching Experience:

  • Professor at Amrita School of Pharmacy, Amrita Vishwa Vidyapeetham, Kochi, India, since April 2022
  • Associate Professor and Assistant Professor at various institutions in India prior to current position

Invited Talks:

  • Presented internationally and nationally on topics related to drug design, molecular docking, and medicinal chemistry.

Awards and Recognition:

  • Recognized with multiple awards including Top 2% Scientists from Stanford, Amrita Publication Research Award, Best International Collaborator Award, Chancellorā€™s Publication Award, Publication Merit Award, and Best Resource Person Award at National College of Pharmacy.

Patents:

  • Granted patents on compositions for neurological disorders and therapeutic agents.

Publications

  1. Elucidating molecular mechanism and chemical space of chalcones through biological networks and machine learning approaches
    • Authors: Manaithiya, A., Bhowmik, R., Acharjee, S., Parkkila, S., Aspatwar, A., Mathew, B.
    • Year: 2024
    • Citations: 0
  2. Machine learning driven web-based app platform for the discovery of monoamine oxidase B inhibitors
    • Authors: Kumar, S., Bhowmik, R., Oh, J.M., Kim, H., Mathew, B.
    • Year: 2024
    • Citations: 3
  3. Development of morpholine ring-bearing halogenated Ī±,Ī²-unsaturated ketones as selective monoamine oxidase-B inhibitors
    • Authors: Lee, J., Parmbil, S.K., Pandit, N.K., Kim, H., Mathew, B.
    • Year: 2024
    • Citations: 0
  4. Isatin-tethered halogen-containing acylhydrazone derivatives as monoamine oxidase inhibitor with neuroprotective effect
    • Authors: Kumar, S., Oh, J.M., Prabhakaran, P., Kim, H., Mathew, B.
    • Year: 2024
    • Citations: 3
  5. MzDOCK: A free ready-to-use GUI-based pipeline for molecular docking simulations
    • Authors: Kabier, M., Gambacorta, N., Trisciuzzi, D., Nicolotti, O., Mathew, B.
    • Year: 2024
    • Citations: 0
  6. Design and Synthesis of the Linezolid Bioisosteres to Resolve the Serotonergic Toxicity Associated with Linezolid
    • Authors: Girase, R.T., Ahmad, I., Oh, J.M., Kim, H., Patel, H.M., Mathew, B.
    • Year: 2024
    • Citations: 0
  7. MAO-B Inhibitor (2E)-3-(4-Bromophenyl)-1-(1H-indol-3-yl) prop-2-en-1-one as a Neuroprotective Agent Against Alzheimerā€™s Disease
    • Authors: Sasidharan, R., Mohanan, R., Kukreti, N., Manju, S.L., Mathew, B.
    • Year: 2024
    • Citations: 0
  8. Correction to: Targeting cellular batteries for the therapy of neurological diseases (Environmental Science and Pollution Research)
    • Authors: Arora, A., Behl, T., Sehgal, A., Mathew, B., Bungau, S.
    • Year: 2024
    • Citations: 0
  9. Chalcones with N-Methylpiperazine Moiety: Synthesis, Monoamine Oxidase Inhibition, Neuroprotective Effect and Computer Simulation Study
    • Authors: Jayan, J., Trisciuzzi, D., Benny, F., Nicolotti, O., Mathew, B.
    • Year: 2024
    • Citations: 0
  10. A structure-based approach to explore novel COX-2 inhibitors using pharmacophore modelling, 3D-QSAR analysis, virtual screening and dynamics simulation study
    • Authors: Krishnendu, P.R., Benny, S., Kumar, S., Zachariah, S.M., Mathew, B.
    • Year: 2024
    • Citations: 3

 

 

Marisa Freitas | Pharmaceutical Sciences | Best Researcher Award

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Dr. Marisa Freitas | Pharmaceutical Sciences | Best Researcher Award

Researcher at LAQV/REQUIMTE/Faculty of Pharmacy of University of Porto, Portugal.

Dr. Marisa Freitas is a distinguished researcher with a PhD in Pharmaceutical Sciences from the University of Porto, specializing in the effects of metals on human neutrophils. She holds an MSc in Analytical Chemistry and a Licenciatura in Agricultural Sciences Engineering. Currently a Contracted Researcher at REQUIMTE LAQV, her research focuses on the therapeutic potential of natural compounds like polyphenols and flavonoids, particularly for inflammatory and metabolic disorders. She has received prestigious awards, including a post-Doc FCT fellowship and an FCT Individual Scientific Employment Stimulus grant. Marisa’s expertise spans experimental design, data analysis, and nanocarrier systems, with proficiency in various lab techniques. She has published over 100 papers, 36 abstracts, and 9 book chapters, and has presented at numerous conferences. Her international recognition includes roles in COST actions, the Global Burden of Disease Studies, and peer-reviewing for over 20 journals.

Professional Profiles:

Education šŸŽ“

Marisa Freitas completed her PhD in Pharmaceutical Sciences from the Faculty of Pharmacy at the University of Porto in 2010, with a thesis on “The effect of metals on human neutrophils,” earning unanimous approval with distinction. She holds an MSc in Analytical Chemistry from the same institution, achieved in 2006 with a thesis on “Estudo da activaĆ§Ć£o de neutrĆ³filos humanos pelo nitrato de nĆ­quel,” awarded with the maximum grade. Additionally, she obtained a Licenciatura in Agricultural Sciences Engineering in 2005, majoring in Animal Nutrition, with a thesis titled “A cor como mĆ©todo de avaliaĆ§Ć£o do valor nutritivo do Corn Gluten Feed,” receiving a grade of 16.

Professional Experience

Marisa Freitas is currently a Contracted Researcher at REQUIMTE LAQV, Faculty of Pharmacy, University of Porto, a position she has held since March 2019. From July 2016 to February 2019, she worked as a Contracted Researcher at the Institute of Agricultural and Agro-Alimentary Sciences and Technologies, University of Porto. Prior to this, she was a Postdoctoral Researcher from January 2012 to June 2016 at the FundaĆ§Ć£o para a CiĆŖncia e a Tecnologia, University of Porto.

šŸ”¬ Research Interests

Marisa Freitas’s research interests focus on the use of natural compounds, such as polyphenols and flavonoids, for their potential therapeutic effects. She investigates their role in preventing and mitigating inflammatory responses, particularly those induced by nanoparticles. Additionally, her work explores the application of these compounds in the treatment of metabolic disorders, such as diabetes mellitus. Her research extends to the development of nanocarrier systems to enhance the bioefficacy of these natural compounds and their impact on key metabolic pathways in conditions like diabesity.

šŸ† Awards and Honors

Marisa Freitas has been recognized with several prestigious awards and honors throughout her career. In 2012, she received a post-Doc FCT fellowship. In 2016, she was hired as an Assistant Researcher for the project “New Technologies for Three Health Challenges of Modern Societies: Diabetes, Drug Abuse, and Kidney Diseases” (NORTE-01-0145-FEDER-000024). In April 2019, she was appointed as an Assistant Researcher for the project “Use of Flavonoids in the Prophylaxis of Intestinal Pro-inflammatory Effects of Silver Nanoparticles” (POCI-01-0145-FEDER-029248). In 2020, Marisa won a grant in the Call for Individual Scientific Employment Stimulus from FCT (2020.04126.CEECIND). Subsequently, in 2021, she became part of the permanent staff at REQUIMTE, a testament to her high scientific competence and contributions to the field.

šŸ› ļø Research Skills

Marisa Freitas possesses a diverse set of research skills that have significantly contributed to her scientific achievements. She is highly skilled in experimental design and data analysis, with a strong focus on the pharmacological and toxicological evaluation of natural compounds. Her expertise extends to the development and optimization of nanocarrier systems for drug delivery, enhancing the bioefficacy of therapeutic agents. Marisa is proficient in various laboratory techniques, including cell culture, flow cytometry, and high-performance liquid chromatography (HPLC). She has extensive experience in supervising research projects and mentoring students, demonstrating her ability to lead and collaborate effectively in scientific research. Additionally, she has a proven track record in publishing high-impact scientific papers and presenting research findings at national and international conferences.

Publications

  1. Pyrazoles have a multifaceted anti-inflammatory effect targeting prostaglandin E2, cyclooxygenases and leukocytesā€™ oxidative burst
    • Authors: Rocha, S., Silva, J., Silva, V.L.M., Freitas, M., Fernandes, E.
    • Year: 2024
  2. Bioactive Compounds and Scavenging Capacity of Adansonia digitata L. (Baobab Fruit) Pulp Extracts against ROS and RNS of Physiological Relevance
    • Authors: Vinha, A.F., Costa, A.S.G., Pimentel, F.B., Fernandes, E., Oliveira, M.B.P.P.
    • Year: 2024
  3. 2-Styrylchromones as inhibitors of Ī±-amylase and Ī±-glucosidase enzymes for the management of type 2 diabetes mellitus
    • Authors: Santos, C.M.M., ProenƧa, C., Freitas, M., Silva, A.M.S., Fernandes, E.
    • Year: 2024
  4. Rheumatoid arthritis molecular targets and their importance to flavonoid-based therapy
    • Authors: Rufino, A.T., Freitas, M., ProenƧa, C., Fernandes, E., Ribeiro, D.
    • Year: 2024
    • Citations: 2
  5. Melanoxetin: A Hydroxylated Flavonoid Attenuates Oxidative Stress and Modulates Insulin Resistance and Glycation Pathways in an Animal Model of Type 2 Diabetes Mellitus
    • Authors: Rocha, S., Amaro, A., Ferreira-Junior, M.D., Matafome, P., Fernandes, E.
    • Year: 2024
  6. The role of flavonoids in the regulation of epithelial-mesenchymal transition in cancer: A review on targeting signaling pathways and metastasis
    • Authors: ProenƧa, C., Freitas, M., Ribeiro, D., Fernandes, E., Ferreira de Oliveira, J.M.P.
    • Year: 2023
    • Citations: 1
  7. Biodistribution and intestinal inflammatory response following voluntary oral intake of silver nanoparticles by C57BL/6J mice
    • Authors: Sousa, A., Azevedo, R., Costa, V.M., Fernandes, E., Freitas, M.
    • Year: 2023
    • Citations: 2
  8. Global, regional, and national burden of osteoarthritis, 1990ā€“2020 and projections to 2050: a systematic analysis for the Global Burden of Disease Study 2021
    • Authors: Steinmetz, J.D., Culbreth, G.T., Haile, L.M., Vos, T., Kopec, J.A.
    • Year: 2023
    • Citations: 108
  9. Applications of silver nanoparticles in daily life
    • Authors: Sousa, A., Carvalho, F., Fernandes, E., Freitas, M.
    • Year: 2023
  10. Novel strategies for managing diabetes mellitus using lipid-based delivery systems as vehicles of polyphenols
    • Authors: Rocha, S., Corvo, M.L., Fernandes, E., Freitas, M.
    • Year: 2023