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Dr. Mohammad-Reza Neadmoghaddam | Nanotechnology | Best Researcher Award

Avicenna Research Institute at Avicenna Research Institute, Iran

Mohammad-Reza Nejadmoghaddam is a highly accomplished researcher specializing in nanomedicine, particularly in the development of targeted drug delivery systems and biopolymer-based formulations. With a Ph.D. in Nanomedicine from Tehran University of Medical Sciences, his research focuses on innovative approaches such as antibody-drug conjugates (ADCs) for cancer immunotherapy and nano-assemblies for wound care. His expertise spans molecular microbiology, nanotechnology, and biomolecule purification, supported by extensive experience in experimental design and data analysis. Mohammad-Reza has received numerous accolades, including grants from prestigious institutions like the Iran National Science Foundation and Avicenna Research Institute. His contributions to the field are underscored by publications in renowned journals and presentations at international conferences. He excels in laboratory techniques such as molecular cloning, protein purification using magnetic beads, and nanoparticle synthesis. Mohammad-Reza Nejadmoghaddam is recognized for his research acumen, collaborative spirit, and dedication to advancing nanomedicine through innovative research and effective scientific communication.

Professional Profiles:

Education

Ph.D. in Nanomedicine, Nanotechnology Research Center, School of Pharmacy, Tehran University of Medical Sciences (TUMS), 2012-2018. Thesis titled “Targeted Drug Delivery Nanomedicine against Prostate Cancer Cell Lines Based on PLAC1 Antibody Drug Conjugate (ADC)”, supervised by Dr. Rassoul Dinarvand, Dr. Amir-Hassan Zarnani, and Dr. Ramin Ghahremanzadeh. MSc in Molecular Microbiology, Azad University, Jahrom Branch, 2003-2006. Thesis titled “Extraction, Molecular Cloning, and small-scale expression of streptokinase gene from Streptococcus equisimilis H46A”, supervised by Dr. Mohammad Hossein Modarressi and Dr. Mohammad Babashamsi. BSc in Microbiology, Azad University, Tonekabon Branch, 1995-1999.

Academic Supervision

Mohammad-Reza Nejadmoghaddam has been actively involved in academic supervision and consultancy roles, primarily focusing on guiding doctoral and master’s students in their research endeavors. Since 2019, he has served as the Main Supervisor for PhD Student Tahereh Zarnoosheh Farahani at Islamic Azad University, overseeing the development of anti-small molecule antibodies and ELISA techniques for pharmacokinetic studies of SN38-containing antineoplastic drugs. Additionally, from 2019 to 2020, he supervised MSc student Fatemeh Mozafari at the Science and Research Branch of Islamic Azad University, where she investigated the antibacterial properties and in vitro toxicity of Graphene oxide on human skin cells. In 2023, Nejadmoghaddam took on the role of Supervisor for PhD student Sara Dadras at the Avicenna Research Institute, focusing on the treatment of immature bovine oocytes using cAMP modulators and forskolin formulations in vitro. Furthermore, in 2022 and 2021, he served as Co-Supervisor for PhD students at Islamic Azad University and Shahid Beheshti University, respectively, contributing to projects involving monoclonal antibody characterization and the effects of training regimens on gene expression in rats.

Research Interest

Mohammad-Reza Nejadmoghaddam’s research interests primarily focus on nanomedicine applications aimed at diagnosing and treating challenging diseases. His work includes developing nano-assemblies of antibody-drug-conjugates (ADC) for cancer immunotherapy and biopolymer-based nano-formulations for advanced wound care and skin dressing. He is also involved in leveraging molecular biology and nanotechnology advancements for biomolecule purification. Additionally, Nejadmoghaddam explores nanomedicine’s potential in reproductive biology and assisted reproductive technologies (ART), aiming to enhance therapeutic outcomes and address critical medical needs.

Award and Honors

Mohammad-Reza Nejadmoghaddam has been recognized with several prestigious awards and grants for his outstanding contributions to nanomedicine and biomedical research. In 2024, he received a grant from the Iran National Science Foundation (INSF) for his project titled “The preparation and characterization of FSK/IBMX-loaded PLGA nanoparticles as a cAMP-elevating nanomedicine for improving IVM.” This project, based at the Nanobiotechnology Research Center, Avicenna Research Institute, Shahid Beheshti University, focuses on advancing nanotechnology applications in medical sciences. In 2023, he was awarded another grant from the Avicenna Research Institute (ARI) for his work on Altrazeal® wound dressing using Nanoflex technology. Additionally, in 2020, he received funding from ACECR for developing alginate-based sponge dressings for high exudate wounds. Nejadmoghaddam’s accolades also include the Iranian Nanotechnology Society’s prize in 2018 for the best research paper published in a top-cited journal, as well as the Distinguished Researcher award from the Avicenna Research Institute in the same year, commemorating his significant contributions on National Doctors’ Day.

Research Skills

Mohammad-Reza Nejadmoghaddam possesses extensive research skills cultivated over years of dedicated study and professional practice in nanomedicine. His expertise spans experimental design, encompassing both controlled experiments and observational studies aimed at advancing drug delivery systems and biopolymer-based formulations. He excels in data analysis, employing quantitative and qualitative methods to extract meaningful insights from complex datasets in molecular microbiology and nanotechnology research. Furthermore, Mohammad-Reza is adept at conducting thorough literature reviews, identifying gaps in knowledge, and contributing novel perspectives to his field. His proficiency extends to a wide array of laboratory techniques, including molecular cloning, protein purification using magnetic beads, and nanoparticle synthesis for targeted drug delivery applications. His track record includes securing funding from prestigious institutions such as the Iran National Science Foundation and Avicenna Research Institute, underscoring his capability in grant writing and funding acquisition. Mohammad-Reza Nejadmoghaddam’s research prowess is complemented by his effective communication skills, demonstrated through publications in reputable journals and presentations at international conferences, reflecting his commitment to advancing nanomedicine through collaborative and innovative research endeavors.

Publications

  • Antibody-Drug Conjugates: Possibilities and Challenges
    • Authors: MR Nejadmoghaddam, A Minai-Tehrani, R Ghahremanzadeh, …
    • Year: 2019
    • Citations: 220
    • Journal: Avicenna Journal of Medical Biotechnology
  • Comparison of the Antibacterial Effects of Nanosilver With 18 Antibiotics on Multidrug Resistance Clinical Isolates of Acinetobacter baumannii
    • Authors: MS Sarah Niakan, Mohammad Niakan, Saeed Hesaraki
    • Year: 2013
    • Citations: 49
    • Journal: Jundishapur Journal of Microbiology
  • Fast and highly efficient purification of 6× histidine-tagged recombinant proteins by Ni-decorated MnFe2O4@SiO2@NH2@2AB as novel and efficient affinity adsorbent
    • Authors: Z Rashid, H Naeimi, AH Zarnani, M Nazari, MR Nejadmoghaddam, …
    • Year: 2016
    • Citations: 36
    • Journal: RSC Advances
  • Production and purification of streptokinase by protected affinity chromatography
    • Authors: M Babashamsi, MH Razavian, MR Nejadmoghaddam
    • Year: 2009
    • Citations: 30
    • Journal: Avicenna Journal of Medical Biotechnology
  • Placenta-specific1 (PLAC1) is a potential target for antibody-drug conjugate-based prostate cancer immunotherapy
    • Authors: MR Nejadmoghaddam, AH Zarnani, R Ghahremanzadeh, R Ghods, …
    • Year: 2017
    • Citations: 29
    • Journal: Scientific Reports
  • Nickel-Salen supported paramagnetic nanoparticles for 6-His-target recombinant protein affinity purification
    • Authors: Z Rashid, R Ghahremanzadeh, MR Nejadmoghaddam, M Nazari, …
    • Year: 2017
    • Citations: 26
    • Journal: Journal of Chromatography A
  • Optimized protocol for soluble prokaryotic expression, purification and structural analysis of human placenta specific-1 (PLAC1)
    • Authors: M Nazari, AH Zarnani, R Ghods, R Emamzadeh, S Najafzadeh, …
    • Year: 2017
    • Citations: 18
    • Journal: Protein Expression and Purification
  • Cloning and overexpression of active recombinant fusion streptokinase: a new approach to facilitate purification
    • Authors: MR Nejadmoghaddam, MH Modarressi, M Babashamsi, M Chamankhah
    • Year: 2007
    • Citations: 14
    • Journal: Pakistan Journal of Biological Sciences
  • Profiling and quantitative evaluation of three Nickel-Coated magnetic matrices for purification of recombinant proteins: helpful hints for the optimized nanomagnetisable matrix …
    • Authors: MR Nejadmoghaddam, M Chamankhah, S Zarei, AH Zarnani
    • Year: 2011
    • Citations: 11
    • Journal: Journal of Nanobiotechnology
  • Bioimaging based on antibody-conjugated amphiphilic polymer-core@shell quantum dots
    • Authors: AH Zarnani, MR Nejadmoghaddam, MM Moghaddam, F Mohammadi, …
    • Year: 2018
    • Citations: 5
    • Journal: Emerging Materials Research
Mohammad-Reza Neadmoghaddam | Nanotechnology | Best Researcher Award

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