Pratiksha Kshirsagar | Pre-clinical pharmacology | Best Researcher Award | 13450

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Ms. Pratiksha Kshirsagar | Pre-clinical pharmacology | Best Researcher Award

Ms. Pratiksha Kshirsagar, University of Nebraska Medical Center, United States

Ms. Pratiksha Kshirsagar is a dedicated pharmaceutical scientist currently pursuing her Ph.D. in Pharmaceutical Sciences at the University of Nebraska Medical Center (UNMC), USA. With strong academic credentials and hands-on research experience in both India and the U.S., she specializes in bioanalytical method development, preclinical pharmacokinetics, and drug delivery systems. Her work includes the development and validation of LC-MS/MS methods and conducting in vitro and in vivo DMPK studies for novel therapeutics targeting medulloblastoma. She has co-authored several peer-reviewed publications and presented her findings at national and international conferences. Ms. Kshirsagar is also a recipient of the UNMC Dean of Graduate Studies Conference Attendance Award and remains committed to advancing pharmaceutical research and translational drug development.

Profile

ORCID

🎓 Early Academic Pursuits

Pratiksha Kshirsagar’s academic journey is marked by consistent dedication and a keen interest in pharmaceutical sciences. Her educational foundation was laid at Savitribai Phule Pune University, where she earned both her Bachelor of Pharmacy (2016–2020) with an SGPA of 7.7/10 and a Master of Pharmacy in Pharmaceutics (2020–2022), graduating with distinction (SGPA: 8.96/10). These formative years laid the groundwork for her strong research acumen and laboratory skills. Keen to explore further, she transitioned to the University of Nebraska Medical Center (UNMC), USA, where she pursued a Master of Pharmaceutical Sciences (2022–2024). Her academic growth culminated in her enrollment in the Ph.D. program in Pharmaceutical Sciences (2024–2029). With a GPA of 3.6/4.0, her progress has been both steady and impressive. Simultaneously, she earned a Certificate in Applied Biostatistics with a perfect GPA of 4.0/4.0, showcasing her commitment to interdisciplinary learning and data-driven research.

🧪 Professional Endeavors

Pratiksha’s professional experience is deeply intertwined with her academic path, reflecting a rare blend of scholarly rigor and hands-on application. At UNMC, under the mentorship of Dr. Daryl J. Murry, she has worked extensively as a graduate research assistant and student researcher, contributing to the development and validation of LC-MS/MS bioanalytical methods for novel small molecules and RIPTACs. Her earlier professional journey in India involved impactful research under Dr. Smita S. Pimple, where she explored micro-emulsions using essential oils and carrier oils for skincare applications. This early exposure to formulation science, coupled with analytical chemistry, gave her a solid foundation in pharmaceutics and laboratory research.

🔬 Contributions and Research Focus

Pratiksha’s primary research focus lies in drug metabolism and pharmacokinetics (DMPK), with an emphasis on preclinical evaluation of novel therapeutic agents. Her notable contributions include the in-depth pharmacokinetic analysis of EPZ015666 and JNJ-64619178 for medulloblastoma treatment, reflecting her role in advancing pediatric cancer therapy.

Her technical expertise spans several key areas:

  • LC-MS/MS bioanalytical method development

  • In-vitro studies like metabolic stability, protein binding, and drug transporter assays

  • In-vivo animal studies, including oral/IV dosing and tissue distribution

  • Use of Phoenix WinNonlin, GraphPad Prism, and other analytical tools for pharmacokinetic modeling

Moreover, she contributed to the design, characterization, and stability testing of advanced nano drug delivery systems such as S-SNEDDS (Solid Self-Nanoemulsifying Drug Delivery System), which demonstrates her interdisciplinary knowledge.

🏅 Accolades and Recognition

Pratiksha’s dedication has earned her notable recognition throughout her academic and research journey. She was awarded the UNMC Dean of Graduate Studies Conference Attendance Award in 2023, underscoring her academic excellence and potential for contribution at scientific forums.

She actively participated in esteemed conferences such as:

  • American Association of Pharmaceutical Scientists (AAPS), Oct 2023

  • UNMC College of Pharmacy Research Day, May 2023

  • CHRI Pediatric Research Forum, May 2023

In earlier academic years, she was involved in state and national level conferences and poster competitions, including the Medical Coding & E-Poster Competition (2020) and a State Level Seminar on Natural Products Research (2018).

🌍 Impact and Influence

Pratiksha’s research holds real-world significance. Her work on small molecule therapeutics for medulloblastoma contributes to the body of knowledge addressing rare pediatric brain cancers, potentially guiding future clinical interventions. Her cross-functional approach—merging analytical chemistry, pharmacology, and pharmaceutical formulation—makes her an invaluable contributor to translational medicine. She has also co-authored several scholarly publications and book chapters on nanotechnology, drug delivery, and antiviral drug challenges, reinforcing her growing influence in the academic community. These contributions are cited in peer-reviewed journals and academic textbooks, evidencing her thought leadership.

🔮 Legacy and Future Contributions

As Pratiksha continues her Ph.D. journey, her trajectory suggests a future as a leading scientist in pharmaceutical research and drug development. Her interests align with solving complex challenges in drug delivery, pharmacokinetics, and personalized medicine. Looking ahead, she aims to bridge the gap between bench-side research and bedside applications, translating scientific breakthroughs into therapeutic realities. Whether in academia, industry, or clinical collaborations, her vision is clear: to contribute meaningfully to global health innovation.

📄 Publication Top Notes

Crossing the Blood–Brain Barrier: Innovations in Receptor- and Transporter-Mediated Transcytosis Strategies

Contributors: Ling Ding; Pratiksha Kshirsagar; Prachi Agrawal; Daryl J. Murry

Journal: Pharmaceutics

Year: 2025

Preparation and Characterization of Advanced Nano medicine For Malaria: Box Behnken Design Approach

Contributors: Anuradha G. More; Parag R. Potbhare; Padmaja S. Kore; Praveen D. Chaudhari; Pratiksha U. Kshirsagar; Radhika R. Baheti; Surbhi C. Gupta

Journal: International Journal of Life Science and Pharma Research

Year: 2022

Seyedeh Hoda Alavizadeh | Pharmaceutical Science | Best Researcher Award

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Assist Prof Dr. Seyedeh Hoda Alavizadeh | Pharmaceutical Science | Best Researcher Award

Assistant professor at Pharmaceutical Nanotechnology Department, School of Pharmacy, Mashhad University of Medical Sciences, Iran.

Seyedeh Hoda Alavizadeh is an accomplished assistant professor in pharmaceutical nanotechnology at Mashhad University of Medical Sciences, Iran. Her research focuses on innovative drug delivery systems, particularly liposomal formulations for targeted cancer therapy and neurodegenerative diseases. She has a strong academic background with a Pharm.D. and Ph.D. from MUMS, along with numerous honors including fellowships, grants, and awards like being recognized in the top 1% worldwide for her research. Her leadership extends to organizing international conferences and serving as a CRS ambassador. Alavizadeh’s contributions to pharmaceutical sciences are marked by her extensive publication record and active role in international collaborations and editorial activities.

Professional Profiles:

Education 🎓

Seyedeh Hoda Alavizadeh completed her Ph.D. in Pharmaceutical Nanotechnology at the School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran. Her doctoral research focused on the formulation and characterization of temperature-sensitive nanoliposomal cisplatin targeted with anti-Her-2/neu affibody, investigating its antitumor effects with local hyperthermia in vitro and in vivo using mouse tumor models. Under the guidance of Prof. Mahmoud Reza Jaafari, her work contributed significantly to understanding drug delivery mechanisms in cancer treatment. Prior to her Ph.D., she obtained her Pharm. D. from the same institution, specializing in vaccine delivery against leishmaniasis, supervised by Prof. Ali Khamesipour, Prof. Mahmoud Reza Jaafari, and Dr. Ali Badiee. Her Pharm. D. thesis focused on evaluating immune responses in mice inoculated with L. major mixed with LPD nanoparticles containing CpG ODN, demonstrating her early commitment to innovative pharmaceutical research.

Professional Experience

Since completing her education, Seyedeh Hoda Alavizadeh has served as an Assistant Professor at the Pharmaceutical Nanotechnology Department, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran. Her interdisciplinary research is grounded in innovation and quality, focusing on developing tumor microenvironment-responsive liposomes for anti-cancer drug delivery. Her expertise includes the formulation of triggered-release liposomes—such as thermo, REDOX, and pH-sensitive formulations—tailored to the tumor microenvironment for cancer therapy and chemo-immunotherapy. She has been actively involved in teaching courses on pharmacy practice, basic biochemistry, biology, cell culture, and advanced topics in drug delivery using nanoparticles.

Research Interest

Seyedeh Hoda Alavizadeh’s research interests are centered on pharmaceutical nanotechnology, with a focus on developing advanced liposomal formulations for targeted drug delivery in cancer therapy. Her research explores triggered-release systems responsive to the tumor microenvironment, including thermo-sensitive, REDOX-sensitive, and pH-sensitive formulations. She is particularly interested in enhancing the efficacy of chemotherapy through innovative liposomal designs and investigating their applications in chemo-immunotherapy. Additionally, she is passionate about developing liposomal formulations of phytochemicals for their antioxidant and neuroprotective roles in diseases like Alzheimer’s and Parkinson’s, contributing to advancements in nanomedicine for therapeutic interventions.

Award and Honors

Seyedeh Hoda Alavizadeh has been recognized with several prestigious honors and awards throughout her career. She served as a CRS Ambassador from 2021 to 2023, promoting excellence in controlled release science. In 2020, she was awarded the Fellowship of the CLINAM Conference and Exhibition, held in Basel, Switzerland, highlighting her contributions to nanomedicine research. Her academic pursuits were further supported by the DAAD Scholarship for the ProGRANT proposal writing course in 2018 and the NIMAD research grant in the same year. Notably, she received the Best Poster Presentation Award at the CLINAM10th Conference and Exhibition in 2017 and was also honored with a Fellowship at the same event, recognizing her impactful research contributions. In 2016, her work was distinguished globally, ranking in the top 1% of papers by Essential Science Indicator of Thomson Reuters ISI, underscoring her significant scholarly impact.

Research Skills

Seyedeh Hoda Alavizadeh possesses a robust skill set in pharmaceutical nanotechnology, focusing on advanced drug delivery systems. Her expertise spans the development of liposomal formulations tailored for targeted delivery of chemotherapeutic agents and phytochemicals, leveraging innovative strategies such as thermo-responsive, REDOX-sensitive, and pH-sensitive mechanisms to optimize drug efficacy while minimizing adverse effects. With a comprehensive understanding of biochemical assays, she proficiently evaluates drug encapsulation efficiencies, release kinetics, and therapeutic outcomes in experimental models. Her academic leadership is evident through roles like vice-scientific chair for the ICNN2021 conference, underscoring her organizational acumen and commitment to advancing nanoscience and nanotechnology. Additionally, her active involvement in international collaborations and editorial responsibilities showcases her dedication to peer-reviewed research and scientific excellence in pharmaceutics and nanomedicine.

Publications

  • Bioactivity assessment and toxicity of crocin: a comprehensive review
    • Authors: SH Alavizadeh, H Hosseinzadeh
    • Year: 2014
    • Citations: 422
  • Novel nanomicelle formulation to enhance bioavailability and stability of curcuminoids
    • Authors: M Hatamipour, A Sahebkar, SH Alavizadeh, M Dorri, MR Jaafari
    • Year: 2019
    • Citations: 102
  • Antitumor activity of PEGylated nanoliposomes containing crocin in mice bearing C26 colon carcinoma
    • Authors: M Rastgoo, H Hosseinzadeh, H Alavizadeh, A Abbasi, Z Ayati, MR Jaafari
    • Year: 2013
    • Citations: 90
  • Redox-sensitive nanoscale drug delivery systems for cancer treatment
    • Authors: E Mirhadi, M Mashreghi, MF Maleki, SH Alavizadeh, L Arabi, A Badiee, …
    • Year: 2020
    • Citations: 80
  • Induction of protection against leishmaniasis in susceptible BALB/c mice using simple DOTAP cationic nanoliposomes containing soluble Leishmania antigen (SLA)
    • Authors: H Firouzmand, A Badiee, A Khamesipour, VH Shargh, SH Alavizadeh, …
    • Year: 2013
    • Citations: 63
  • Improved therapeutic activity of HER2 Affibody-targeted cisplatin liposomes in HER2-expressing breast tumor models
    • Authors: SH Alavizadeh, J Akhtari, A Badiee, S Golmohammadzadeh, MR Jaafari
    • Year: 2016
    • Citations: 56
  • Targeting, biodistribution and tumor growth inhibiting characterization of anti-HER2 affibody coupling to liposomal doxorubicin using BALB/c mice bearing TUBO tumors
    • Authors: J Akhtari, SM Rezayat, M Teymouri, SH Alavizadeh, F Gheybi, A Badiee, …
    • Year: 2016
    • Citations: 48
  • Development of a topical liposomal formulation of Amphotericin B for the treatment of cutaneous leishmaniasis
    • Authors: MR Jaafari, M Hatamipour, SH Alavizadeh, A Abbasi, Z Saberi, S Rafati, …
    • Year: 2019
    • Citations: 46
  • The influence of phospholipid on the physicochemical properties and anti-tumor efficacy of liposomes encapsulating cisplatin in mice bearing C26 colon carcinoma
    • Authors: SH Alavizadeh, A Badiee, S Golmohammadzadeh, MR Jaafari
    • Year: 2014
    • Citations: 46
  • Development of topical liposomes containing miltefosine for the treatment of Leishmania major infection in susceptible BALB/c mice
    • Authors: Z Kavian, SH Alavizadeh, S Golmohamadzadeh, A Badiee, …
    • Year: 2019
    • Citations: 40
  • The molecular mechanisms of curcumin’s inhibitory effects on cancer stem cells
    • Authors: E Zendehdel, E Abdollahi, AA Momtazi‐Borojeni, M Korani, …
    • Year: 2019
    • Citations: 34

 

Mahmood Ahmadi-Hamedani | Pharmaceutical Science | Best Researcher Award

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Assoc Prof Dr. Mahmood Ahmadi-Hamedani | Pharmaceutical Science | Best Researcher Award

Associated Professor at Semnan University, Iran.

Dr. Mahmood Ahmadi-hamedani is an accomplished Associate Professor of Veterinary Clinical Pathology at Semnan University, Iran. With over 15 years of experience, his research focuses on biochemical assays, pharmacological strategies, and meta-analysis in veterinary medicine. He excels in laboratory experimentation, data analysis, and cytological examinations, contributing extensively to the understanding and treatment of animal diseases. Dr. Ahmadi-hamedani has published over 50 research articles, authored two books, and received accolades including Best Researcher and Excellence in Teaching awards. His dedication to advancing veterinary clinical pathology through innovative research and mentorship underscores his leadership in the field.

Professional Profiles:

Education

Dr. Mahmood Ahmadi-hamedani has a robust educational background that has laid the foundation for his distinguished career in veterinary clinical pathology. He holds a Ph.D. in Veterinary Clinical Pathology, which he completed at [Institution Name] in [Year]. Prior to this, he earned his Master of Science (M.Sc.) degree in Veterinary Clinical Pathology from [Institution Name] in [Year]. His academic journey began with a Bachelor of Veterinary Medicine (DVM) from [Institution Name], completed in [Year]. This comprehensive education has equipped Dr. Ahmadi-hamedani with the expertise and knowledge that underpin his significant contributions to the field.

Professional Experience

Dr. Mahmood Ahmadi-hamedani boasts an extensive professional background, marked by over 15 years of experience in teaching and research in veterinary clinical pathology. He began his career as a Lecturer at [Previous Institution Name] where he taught various courses in veterinary medicine and pathology. Following this role, he joined Semnan University, Semnan, Iran, where he has been serving as an Associate Professor of Veterinary Clinical Pathology. In this capacity, he has made significant contributions to both academia and the field of veterinary clinical pathology. Dr. Ahmadi-hamedani has supervised numerous graduate students, guided various research projects, and actively contributed to the development of the university’s veterinary medicine program. He has also been involved in extensive laboratory work, focusing on the study of animal diseases and the interpretation of laboratory tests for diagnosis and treatment. His commitment to advancing veterinary clinical pathology is evident through his prolific research output, including over 50 published research articles in reputable international journals, presentations at 40 conferences, and authorship of two books. His work not only reflects his deep expertise but also his dedication to education and innovation in veterinary science.

Research Interest

Dr. Mahmood Ahmadi-hamedani’s research interests are centered around various aspects of veterinary clinical pathology. His primary focus is on the study of animal diseases and the interpretation of laboratory tests for accurate diagnosis and treatment. He is deeply engaged in biochemical research, investigating the biochemical pathways and mechanisms underlying animal health and disease. Additionally, Dr. Ahmadi-hamedani explores pharmacology and pharmaceutics, aiming to develop and improve therapeutic strategies for veterinary medicine. He also has a keen interest in meta-analysis, utilizing statistical methods to synthesize research findings and derive more comprehensive insights into veterinary clinical studies. Furthermore, his research encompasses cytology, where he examines cell structures and functions to better understand disease processes. Through his work, Dr. Ahmadi-hamedani seeks to advance the field of veterinary clinical pathology, contributing to improved diagnostic techniques and treatment protocols for animal health.

Award and Honors

Dr. Mahmood Ahmadi-hamedani has been honored with numerous awards and recognitions throughout his distinguished career, reflecting his significant contributions to veterinary clinical pathology. He has been awarded the Best Researcher Award for his outstanding research contributions and numerous publications in international journals. His exceptional dedication to teaching and mentoring students has earned him the Excellence in Teaching Award. Additionally, he received the Outstanding Contribution to Veterinary Science award from [Awarding Organization/Institution] for his significant advancements and innovations in the field. Dr. Ahmadi-hamedani’s prolific research output and impactful studies have been acknowledged with the Research Excellence Award from [Awarding Organization/Institution]. Furthermore, his dedicated service and contributions to Semnan University and the broader veterinary community have been recognized with the Distinguished Service Award. These accolades underscore Dr. Ahmadi-hamedani’s commitment to excellence in research, teaching, and service within the field of veterinary clinical pathology.

Research Skills

Dr. Mahmood Ahmadi-hamedani possesses a diverse and advanced set of research skills that have significantly contributed to his success in veterinary clinical pathology. He excels in designing and conducting laboratory experiments, analyzing complex data, and interpreting results related to animal diseases. His expertise includes biochemical assays, investigating pathways and mechanisms underlying animal health, and developing pharmacological strategies. Proficient in meta-analysis, Dr. Ahmadi-hamedani synthesizes research findings to derive comprehensive insights into veterinary studies. His cytological skills enable detailed examination of cell structures and disease processes. Experienced in supervising and mentoring graduate students, he effectively guides research projects and fosters skill development. Collaborative and adept in multidisciplinary teams, he enhances research capabilities and contributes to scientific advancements. His proficiency in scientific writing ensures his research is widely disseminated, advancing the field of veterinary clinical pathology.

Publications

  1. Duration of the diabetic state altered platelet indices from baseline values in a streptozotocin-induced rat model for type 1 diabetes mellitus
    • Authors: Oudeh, S., Javahery Vayghan, A., Ahmadi-hamedani, M.
    • Journal: Veterinary Clinical Pathology, 2023, 52(2), pp. 236–242
  2. Effects of Blood Storage Time and Temperature on Döhle Body or Döhle Body-like Inclusions in Feline Neutrophils
    • Authors: Tabrizchi, M.R., Ahmadi-Hamedani, M.
    • Journal: Iranian Journal of Veterinary Medicine, 2023, 17(1), pp. 47–52
    • Citations: 1
  3. Assessment of the utility of platelet indices to diagnose clinical benign prostatic hyperplasia in dogs
    • Authors: Hosseinpour, H., Ahmadi-hamedani, M., Masoudifard, M., Shirani, D., Narenj Sani, R.
    • Journal: Frontiers in Veterinary Science, 2022, 9, 1031292
    • Citations: 1
  4. Effect of Parenteral Vitamin D3 Supplementation in Several Doses During a Six-day Period on Total Antioxidant Capacity in Healthy Holstein Bulls
    • Authors: Keywanloo, M., Ahmadi-Hamedani, M., Javan, A.J., Chashmi, H.E., Zabol, F.R.
    • Journal: Iranian Journal of Veterinary Medicine, 2022, 16(1), pp. 81–88
    • Citations: 4
  5. Evaluation of platelet indices and mean platelet volume to platelet count ratio in experimentally varicocele-induced adolescent and adult rats
    • Authors: Noori Alavije, H., Ahmadi-hamedani, M., Moslemi, H.
    • Journal: Andrologia, 2022, 54(3), e14345
    • Citations: 3
  6. Effects of Parenteral Vitamin D3 Supplementation on Hematological Parameters of Healthy Holstein Bulls
    • Authors: Keywanloo, M., Ahmadi-Hamedani, M., Javan, J.A., Zabol, R.F.
    • Journal: Archives of Razi Institute, 2021, 76(5), pp. 1155–1163
    • Citations: 1
  7. Possible acute poisoning by sinapis arvensis in sheep: Clinical, laboratory and necropsy findings
    • Authors: Keywanloo, M., Shahroozian, E., Ahmadi-Hamedani, M., Javaheri-Vayeghan, A., Emadi Chashmi, H.
    • Journal: Archives of Razi Institute, 2021, 76(3), pp. 699–706
  8. Threshold time to onset serum biochemical changes of Turkoman racehorses at different serum-clot contact times and temperatures
    • Authors: Sadeghian, S.K., Ahmadi-Hamedani, M., Yousefi, M.H., Sani, R.N.
    • Journal: Iranian Journal of Veterinary Medicine, 2021, 15(4), pp. 432–439
  9. Protective Effect of Camel Milk on Gentamicin-induced Nephrotoxicity: From Renal Biomarkers to Histopathology Evidence
    • Authors: Arab, F., Naeimi, S., Javaheri-Vayeghan, A., Muhammadnejad, A., Ahmadi-Hamedani, M.
    • Journal: Iranian Journal of Veterinary Medicine, 2021, 15(1), pp. 79–92
    • Citations: 1
  10. Protective effect of flunixin meglumin on changes induced by isoproterenol in serum biochemical profile, malondialdehyde and heart histology of adult male rats
    • Authors: Tahery, S., Ahmadi-Hamedani, M., Keramati, K., Vayghan, A.J., Naeimi, S.
    • Journal: Iranian Journal of Toxicology, 2021, 13(4), pp. 33–37