Ricercatore a Tempo Determinato Cat. B at University of Turin, Italy.
Amedeo De Nicolò, born on April 20, 1987, is an Italian researcher currently affiliated with the University of Turin. He holds a PhD in Medicine and Experimental Therapy and a Master’s degree in Cellular and Molecular Biology. De Nicolò specializes in pharmacology, focusing on pharmacokinetics and pharmacogenetics. His research interests include developing bioanalytical methods for Therapeutic Drug Monitoring (TDM) and studying drug interactions and pharmacokinetic/pharmacodynamic evaluations. Throughout his career, he has contributed significantly to clinical pharmacology through various research projects, publications, and participation in international collaborations. In addition to his research, De Nicolò has a strong teaching background, having taught pharmacology courses at the University of Turin and participated in a Master’s program related to biological product control in the industry. He is also an active member of several scientific societies and working groups, including the Italian Society of Pharmacology and the international research consortium VirTUAL.
Professional Profiles:
Education
Amedeo De Nicolò completed his PhD in Medicine and Experimental Therapy from the University of Turin in January 2017. His dissertation focused on the “Pharmacokinetics and Pharmacogenetics of Anti-HCV Treatments,” receiving positive evaluations. Prior to his doctorate, he earned a Master’s degree in Cellular and Molecular Biology, with a Biomedical curriculum, from the same university in October 2011. His master’s thesis titled “Identificazione di Nuovi Parametri Farmacocinetici per la Valutazione Precoce del Rischio di Anemizzazione in Pazienti Sottoposti a Terapia Anti-HCV Standard” was awarded the highest honors, graduating with a score of 110/110 cum laude. Additionally, he holds a Bachelor’s degree in Biological Sciences from the University of Turin, obtained in December 2009. Throughout his academic journey, De Nicolò acquired substantial competencies in biological sciences, clinical pharmacology, laboratory medicine, and statistics. In August 2020, he also achieved professional licensure as a Biologist, further solidifying his qualifications in the field.
Professional Experience
Amedeo De Nicolò is currently a fixed-term researcher (type B) at the University of Turin, specializing in pharmacokinetics and pharmacogenetics. He has been involved in clinical pharmacology research since his internship for his master’s thesis in 2010-2011. From March 2022, he has held his current position at the Department of Medical Sciences, focusing on the development, validation, and application of bioanalytical methods in liquid chromatography for Therapeutic Drug Monitoring (TDM). Prior to this, he was a research fellow from July 2017 to February 2022 at the same institution. During this period, he contributed significantly to pharmacokinetic studies, particularly related to drug-drug interactions and the pharmacokinetic/pharmacodynamic evaluations of antiviral and tuberculosis treatments under the international DERIVE project. De Nicolò has also provided clinical consultancy in interpreting TDM results and has actively participated in the ISO certification processes for biomedical diagnostic kit validations. His extensive experience includes conducting routine drug analysis and providing clinical pharmacological advice since 2012. In addition to his research, he has taught pharmacology modules at the University of Turin for various nursing programs and a master’s course, contributing to academic education alongside his research duties.
Research Interest
Amedeo De Nicolò’s research interests lie primarily in the fields of pharmacokinetics and pharmacogenetics, focusing on clinical pharmacology. His work involves the development, validation, and application of bioanalytical methods using liquid chromatography for Therapeutic Drug Monitoring (TDM). He is particularly interested in studying drug-drug interactions, evaluating pharmacokinetic and pharmacodynamic relationships, and interpreting clinical data through statistical analysis. De Nicolò is also engaged in research related to the pharmacokinetics of antiviral treatments and the intracellular measurement of anti-infective drugs. His involvement in international research consortia, such as VirTUAL and the COVID-19 Mass Spectrometry Coalition, highlights his commitment to advancing knowledge in these areas. Additionally, De Nicolò’s research extends to the standardization of methodological approaches in TDM, contributing to the enhancement of clinical practices and patient care.
Award and Honors
Amedeo De Nicolò has received several notable awards and honors throughout his career, reflecting his significant contributions to the field of clinical pharmacology. He obtained the National Scientific Qualification as Associate Professor in the sector of Pharmacology, Clinical Pharmacology, and Pharmacognosy (05/G1) on November 6, 2018. This achievement recognizes his expertise and leadership in pharmacological research. Furthermore, De Nicolò became a licensed Biologist on August 12, 2020, showcasing his professional qualifications in biological sciences. His work is also distinguished by his active membership in prominent scientific societies, such as the Italian Society of Pharmacology (SIF) and the Italian Society of Clinical Biochemistry (SIBioC), where he continues to contribute to the advancement of pharmacological sciences.
Research skills
Amedeo De Nicolò possesses a robust set of research skills honed through extensive experience in clinical pharmacology. His expertise includes the development, validation, and application of bioanalytical methods in liquid chromatography for Therapeutic Drug Monitoring (TDM), adhering to ISO 9001 and ISO 13485 standards. He excels in pharmacokinetics and pharmacogenetics, focusing on drug interactions, efficacy, and toxicity. De Nicolò is proficient in statistical analysis and the interpretation of clinical and pharmacogenetic data. Additionally, he has a strong background in conducting and coordinating pharmacokinetic studies, including those involving intracellular drug measurements and therapeutic drug monitoring in various medical contexts. His skills are complemented by his ability to write and publish scientific articles, contributing significantly to the body of knowledge in clinical pharmacology.
Publications
- Pharmacogenetics of tenofovir drug transporters in the context of HBV: Is there an impact?
- Authors: Cusato, J., Manca, A., Palermiti, A., Boglione, L., D’Avolio, A.
- Year: 2024
- Citations: 0
- Cannabinoid levels description in a cohort of patients with chronic and neuropathic pain treated with Cannabis decoction: A possible role of TDM
- Authors: Manca, A., Valz, C., Chiara, F., Cusato, J., D’Avolio, A.
- Year: 2024
- Citations: 0
- Pharmacokinetics and Safety of Twice-daily Ritonavir-boosted Atazanavir with Rifampicin
- Authors: Gausi, K., Mugerwa, H., Siccardi, M., Denti, P., Waitt, C.
- Year: 2024
- Citations: 1
- Comparative Performance Assessment of Novel Fluorescence Immunoassay POCTs for Measuring Circulating Levels of Vitamin-D
- Authors: Palermiti, A., Manca, A., Mastrantonio, F., De Nicolò, A., D’Avolio, A.
- Year: 2024
- Citations: 0
- Pharmacokinetics of tecovirimat in subjects with Mpox
- Authors: Tempestilli, M., Mondi, A., D’Avolio, A., Vaia, F., Antinori, A.
- Year: 2024
- Citations: 0
- Switching from tenofovir disoproxil fumarate to tenofovir alafenamide fumarate in a cohort of patients with HBV infection: A retrospective study
- Authors: Stroffolini, G., Dodaro, V., De Nicolò, A., D’Avolio, A., Boglione, L.
- Year: 2024
- Citations: 0
- Pharmacokinetics and pharmacogenetics of high-dosage tedizolid for disseminated nocardiosis in a lung transplant patient
- Authors: Corcione, S., Vita, D., De Nicolò, A., D’Avolio, A., De Rosa, F.G.
- Year: 2023
- Citations: 0
- Experimental pharmacology in precision medicine
- Authors: Urbaniak, A., Thummel, K.E., Alade, A.N., Sheppard, D.N., Jarvis, M.F.
- Year: 2023
- Citations: 1
- Stability Study of Fosfomycin in Elastomeric Pumps at 4 °C and 34 °C: Technical Bases for a Continuous Infusion Use for Outpatient Parenteral Antibiotic Therapy
- Authors: Manca, A., Palermiti, A., Mula, J., De Nicolò, A., D’Avolio, A.
- Year: 2023
- Citations: 0
- Vitamin D impact in affecting clozapine plasma exposure: A potential contribution of seasonality
- Authors: Manca, A., Mula, J., Palermiti, A., Cusato, J., D’Avolio, A.
- Year: 2023
- Citations: 0