Link University | Italy
Ylenia Della Rocca is an Associate Professor of Histology and Embryology and Physiology whose research profile is internationally recognized in the fields of stem cell biology, regenerative medicine, and advanced in vitro modeling for precision medicine. Her scientific activity is strongly interdisciplinary, integrating histology, embryology, molecular biology, biomaterials, and translational medicine, with a particular focus on induced pluripotent stem cells (iPSCs), extracellular vesicles, and 3D culture systems. Her core research line centers on the reprogramming of autologous human gingival mesenchymal stem cells into iPSCs and their differentiation toward functional cell types, especially cardiomyocytes and neural lineages. This work has led to innovative strategies for cardiac regeneration and personalized regenerative therapies, culminating in a patented non-integrative reprogramming and cardiomyogenic differentiation process. Through advanced molecular and morphological analyses, her studies elucidate the signaling pathways governing cell fate, inflammation, hypoxia response, and extracellular matrix remodeling. A distinctive element of her research is the development and application of organ-on-a-chip and tissue-on-a-chip platforms, including bone-on-a-chip and cardiac models, to study disease mechanisms, environmental pollutant toxicity, and therapeutic responses. Within national and international projects, she has contributed to the creation of physiologically relevant in vitro systems that reduce reliance on animal models while increasing translational relevance. Her work on environmental pollutants, such as bisphenol A and pesticides, has clarified their impact on inflammatory, apoptotic, and epigenetic pathways in stem cells and endothelial models.
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