Dr. Zu-Chian Chiang | Biochemistry | Best Researcher Award

Dr. Zu-Chian Chiang, Fujian Normal University, China

Dr. Zu-Chian Chiang is a postdoctoral fellow at the Biomedical Research Center of Southern China, Fujian Normal University, China, with a rich background in materials and chemical engineering. His research contributions span antibody-drug conjugates (ADCs), functional peptide synthesis, biomaterials for regenerative medicine, and aptamer-based cancer therapy. His work has geographic impact across Taiwan and Mainland China, contributing to translational medicine and oncology through collaborative efforts with prestigious institutions like Academia Sinica and National Taiwan University. His applied research in ADCs and biomaterial scaffolds directly supports cancer treatment innovations. Notable projects include the development of CD47-targeting ADCs for non-small cell lung cancer, and thalidomide-PD1 combinations for enhanced immunotherapy. His publications in Frontiers in Oncology, PLOS ONE, and Current Pharmaceutical Biotechnology highlight his influence in drug delivery and cancer therapeutics. In the vector control domain, his scaffold research contributes to potential localized drug delivery systems. Dr. Chiang has received awards such as the Science and Technology Commissioner honor from Quanzhou and the Biotech Elite Training Award. His achievements exemplify impactful biomedical research with real-world therapeutic implications.

Profile

Scopus

🌱 Early Academic Pursuits

Dr. Zu-Chian Chiang embarked on his scientific journey with a passion for chemistry and materials science. He earned his Master’s Degree in Chemistry from Tunghai University, Taiwan (2005–2007), under the guidance of Prof. Feng-Di Lung. Building on this solid foundation, he pursued his Ph.D. in Materials and Chemical Engineering at National United University, Taiwan (2008–2014). During his doctoral studies, he was mentored by Prof. An-Chong Chao and co-advised by Dr. Guo-Chung Dong, focusing on biomaterials and nanomedicine.

Even as a student, Dr. Chiang demonstrated exceptional academic capabilities, earning scholarships and recognition for his innovative research. His academic training laid the groundwork for his future contributions in biomedical engineering and cancer therapeutics.

🧪 Professional Endeavors

Dr. Chiang has held several prestigious postdoctoral positions. His professional journey reflects a commitment to interdisciplinary collaboration and translational research:

Postdoctoral Fellow at the Biomedical Research Center of Southern China, Fujian Normal University (2019–Present), working under Prof. Qi Chen.
Postdoctoral Fellow at the Institute of Biological Chemistry, Academia Sinica, Taiwan (2016–2019), contributing to the Taiwan Protein Project (TPP) and the Technical Support Platform Spindle Project (TSPA).
Postdoctoral Fellow at the Clinical Trial Center, National Taiwan University Hospital (2015–2016), supported by Taiwan’s prestigious Biotech Elite Training Program.

Throughout these roles, Dr. Chiang has engaged in cutting-edge biomedical research with direct implications for drug development and clinical applications.

🔬 Contributions and Research Focus

Dr. Chiang’s research centers on innovative therapeutic materials and drug delivery systems, particularly in cancer therapy. His core interests include:

Antibody-Drug Conjugates (ADCs): Targeted cancer therapies such as HER2-positive and CD47-specific ADCs.
Functional Peptide Synthesis for bone tissue engineering and cancer inhibition.
Bio-Micro-Macro Molecular Materials for regenerative medicine.
Aptamer Development as modulators in therapeutic settings.

Notable publications include research on CD47-targeting ADCs (Frontiers in Oncology, 2022) and HER2-positive ADCs (PLOS ONE, 2020). His work on dexamethasone-immobilized chitosan scaffolds and chitosan-caffeic acid hybrids also provides valuable insights into localized drug delivery and tissue engineering.

🏆 Accolades and Recognition

Dr. Chiang’s dedication has been acknowledged through numerous awards:

🥇 Science and Technology Commissioner, Quanzhou, Fujian Province (2020)
🥇 Biotech Elite Training Award, National Taiwan University & Ministry of Science and Technology (2016)
🥇 Chung Hwa Rotary Doctoral Program Award, Taiwan (2012)
🥇 Outstanding Doctoral Scholarship, National United University (2010)
🥇 Master’s Program Scholarship, Hunan Fellow Association of Taiwan (2007)
🥇 Rotary Leadership Award, Miaoli Southeastern Xindong Satellite Rotary Club (2017)

These accolades affirm his position as a respected figure in the fields of biomedical chemistry and translational medicine.

🌍 Impact and Influence

Dr. Chiang’s work has made a geographic impact spanning Taiwan and Mainland China. His collaborative research in academia and clinical centers bridges the gap between laboratory research and therapeutic application. He actively contributes as a peer reviewer for the International Journal of Biological Macromolecules, influencing scientific standards and publication quality globally.

He is also engaged in community service through leadership in Rotary International, fostering science-driven community development and education.

🌟 Legacy and Future Contributions

Dr. Chiang’s legacy is being built on the foundation of scientific excellence, mentorship, and translational impact. His research not only pushes the boundaries of biomedical engineering but also aims to enhance the effectiveness of cancer treatments in clinical practice. With a commitment to developing next-generation targeted therapies and biomaterial scaffolds, Dr. Chiang is poised to shape the future of personalized medicine and regenerative technologies.

Looking ahead, he aims to establish interdisciplinary collaborations and contribute to global health initiatives, making life-saving therapies more effective and accessible.

Publication Top Notes

Development of Novel CD47-Specifific ADCs Possessing High Potency Against Non-Small Cell Lung Cancer in vitro and in vivo.

Author: Z.C., Chiang, Zu Chian, S., Fang, Shubin, Y., Shen, Yangkun, … J., Lin, Jizhen, Q., Chen, Qi

Journal: Frontiers in Oncology,

Year: 2022

Preparation and characterization of dexamethasone-immobilized chitosan scaffold

Author: Z.C., Chiang, Zu Chian, S., Yu, Shuhuei, A., Chao, Anchong, G.C., Dong, Guo Chung

Journal: Journal of Bioscience and Bioengineering,

Year: 2012

Dr. Takeshi Chiba | Life Sciences | Best Researcher Award

Associate Professor at Juntendo University, Japan

Dr. Takeshi Chiba is an Associate Professor and Assistant Director at Juntendo University’s Laboratory of Clinical Pharmacology and Department of Pharmacy. He earned his pharmacist’s license in 1999 and a Ph.D. in Pharmaceutical Sciences in 2002 from Josai University. His professional journey includes roles at Iwate Medical University Hospital, Iwate Medical University, Hokkaido University of Science, and Juntendo University. Dr. Chiba’s research focuses on the physiological functions of mammary epithelial cells during lactation, including the synthesis of norepinephrine and the effects of psychological stress and smoking on milk composition. His contributions have led to significant findings in cell biology and pharmacology, reflected in 42 published journal articles and numerous awards. He is a member of several professional societies and has been recognized for his work with academic awards and publications.

Professional Profiles:

🎓 Education

Dr. Takeshi Chiba earned his Pharmacist’s license from Josai University in Saitama, Japan, in March 1999. He then pursued advanced studies at the same institution, culminating in a Ph.D. in Pharmaceutical Sciences, which he completed in March 2002.

Professional Experience

Dr. Takeshi Chiba began his career as a pharmacist at Iwate Medical University Hospital in Japan, serving from April 2002 to March 2009. He transitioned to an academic role as an Assistant Professor in the Department of Clinical Pharmaceutics at Iwate Medical University from April 2009 to March 2019. He then moved to Hokkaido University of Science, where he was a Lecturer in the Department of Clinical Pharmaceutics from April 2019 to March 2023. Since April 2023, Dr. Chiba has been serving as an Associate Professor in the Laboratory of Clinical Pharmacology at the Faculty of Pharmacy, Juntendo University, while also holding the position of Assistant Director at the Department of Pharmacy, Juntendo University Hospital.

Research Interest

Dr. Takeshi Chiba’s research interests focus on clinical pharmacology, particularly the physiological and biochemical aspects of lactation and its impact on infant health. His notable research includes the discovery that mammary epithelial cells synthesize and secrete norepinephrine into milk during lactation, a previously unknown function. He also investigates the effects of psychological stress on microRNA expression in milk, specifically how decreased miR-148a levels influence intestinal tight junction protein regulation in infants. Additionally, his research addresses how smoking affects milk composition by increasing miR-210 expression in mammary epithelium and its implications for infant nutrition and health.

Award and Honors

Dr. Takeshi Chiba has received notable recognition for his contributions to the field of clinical pharmacology. In June 2019, he was honored with an academic award from the Iwate Society of Hospital Pharmacists, reflecting his significant achievements and impact in his area of expertise.

Research Skills

Dr. Takeshi Chiba’s research skills encompass a diverse range of expertise in clinical pharmacology, nutrition, and cell biology. He is proficient in the analysis of physiological functions, including the synthesis and secretion of norepinephrine in mammary epithelial cells and the impact of psychological stress and smoking on milk composition. Dr. Chiba is adept at investigating the regulatory effects of microRNAs on tight junction proteins in infants’ intestines. His research methods involve a combination of experimental and analytical techniques to understand and innovate in the fields of pharmacology and health science.

Publications

“Smoking-induced suppression of β-casein in milk is associated with an increase in miR-210-5p expression in mammary epithelia”
- Authors: Chiba, T., Takaguri, A., Mikuma, T., Kimura, T., Maeda, T.
- Year: 2024
“Human Milk Exosomes Induce ZO-1 Expression via Inhibition of REDD1 Expression in Human Intestinal Epithelial Cells”
- Authors: Chiba, T., Maeda, T.
- Year: 2023
“Suppression of milk-derived miR-148a caused by stress plays a role in the decrease in intestinal ZO-1 expression in infants”
- Authors: Chiba , T. , Takaguri , A. , Kooka , A. , Wada
- Year: 2022
“Expression profiles of hsa-miR-148a-3p and hsa-miR-125b-5p in human breast milk and infant formulae”
- Authors: Chiba, T., Kooka, A., Kowatari, K., Sato, H., Wada, S.
- Year: 2022
“Renin-angiotensin system inhibitors may have an advantage over calcium channel blockers in reducing proteinuria in gastric cancer patients receiving ramucirumab”
- Authors: Chiba, T., Ujiie, H., Yaegashi, Y., Tasaki, Y., Sato, H.
- Year: 2022
“Analysis of risk factors for skin disorders caused by anti-epidermal growth factor receptor antibody drugs and examination of methods for their avoidance”
- Or
- Year: 2021
“Switching from Intravenous to Oral Tacrolimus Reduces its Blood Concentration in Paediatric Cancer Patients”
- Authors: Ujiie, H., Nihei, S., Nishiya, N., Chiba, T., Kudo, K.
- Year: 2021
“Norepinephrine transporter expressed on mammary epithelial cells incorporates norepinephrine in milk into the cells”
- Authors: Chiba, T., Takaguri, A., Maeda, T.
- Year: 2021
“Physiologic changes in serotonin concentrations in breast milk during lactation”
- Authors: Maeda, T., Shioyama, A., Tairabune, T., Kudo, K., Chiba, T.
- Year: 2020
“Cancer cachexia may hinder pain control when using fentanyl patch”
- Authors: Chiba, T., Takahashi, H., Tairabune, T., Ueda, H., Kudo, K.
- Year: 2020

Zu-Chian Chiang | Biochemistry | Best Researcher Award | 13347